Qatar Airways currently has some interesting Open Jaws from their US destinations to Asia and returning (or continuing) to Europe.
Here is an example we priced out in May 2017 via Google Flights for $471.
It also works from Europe to Asia and ‘returning’ to the US. If you have a round-the-world itinerary planned this could be a great tool.
Keep in mind that Qatar does give you a free transit hotel and a free city tour if you have a long layover. You won’t be able to get into the extra nice Qatar Business Class lounge though even if you have OneWorld status.